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Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. This article has been cited by other articles in PMC. We thus investigated the association of these loci with incident CKD in 26, individuals of European ancestry free of CKD at baseline drawn from eight population-based cohorts followed for a median of 7.

In summary, the majority of eGFR-related loci are either associated or show a strong trend towards association with incident CKD, but have modest associations with ESRD in individuals of European descent. Additional work is required to characterize the association of genetic determinants of CKD and ESRD at different stages of disease progression.

Unraveling the genetic underpinning of risk for these diseases Online dating bayreuth dating scan without referral lead to the identification of novel bayrwuth and thus diagnostic and therapeutic tools. We have previously identified 16 genetic markers in association with kidney function and prevalent CKD in general population studies. Therefore, we have datinh analyzed the association of these markers with the initiation of CKD in more than 26, individuals from the general population using serial estimations of kidney function, and with ESRD in four case-control studies in subjects of European ancestry 3, cases, 4, controls. We show that many of the 16 markers are also associated or show a strong trend towards association with initiation of CKD, while only 2 markers are nominally associated with ESRD.

Further work is required to characterize the association of genetic determinants of different stages of CKD progression. Introduction Chronic kidney disease CKD and end stage renal disease ESRD are associated with significant cardiovascular morbidity and mortality, with substantial economic burden [1] — [4].